Synthesis of 1-(3, 4-dihydroxy-5-nitrophenyl)-2-phenyl-ethanone and derivatives as potent and long-acting peripheral inhibitors of catechol-O-methyltransferase

…, N Borges, AP Freitas, P Soares-da-Silva

Index: Guion, Tina S.; Koller, Madlene U.; Lachicotte, Rene J.; Rutledge, Robin N.; Hildebran, Karen C.; Le, Phuong H.; Beam, Charles F. Synthetic Communications, 1996 , vol. 26, # 9 p. 1753 - 1762

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Citation Number: 52

Abstract

... Department of Research & Development, BIAL, 4745-457 S. Mamede do Coronado, Portugal. J. Med ... catecholic substrate via an S N 2-type reaction, giving rise to O-methylated products and S-adenosylhomocysteine (SAH ... 11, N-NH-Ph-(4-CF 3 ), 173−175, AcOH, C 21 H 16 N 3 F ...

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