Total syntheses of amphidinolides B1, B4, G1, H1 and structure revision of amphidinolide H2

A Fürstner, LC Bouchez, L Morency…

Index: Fuerstner, Alois; Bouchez, Laure C.; Morency, Louis; Funel, Jaques-Alexis; Liepins, Vilnis; Poree, Francois-Hugues; Gilmour, Ryan; Laurich, Daniel; Beaufils, Florent; Tamiya, Minoru Chemistry - A European Journal, 2009 , vol. 15, # 16 p. 3983 - 4010

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Citation Number: 74

Abstract

Abstract Nature is a pretty unselective “chemist” when it comes to making the highly cytotoxic amphidinolide macrolides of the B/G/H series. To date, 16 different such compounds have been isolated, all of which could now be approached by a highly convergent and largely catalysis-based route (see figure). This notion is exemplified by the total synthesis of five prototype members of this family.

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