Fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D1

C Aubry, AJ Wilson, D Emmerson, E Murphy…

Index: Aubry, Carine; Wilson, A. James; Emmerson, Daniel; Murphy, Emma; Chan, Yu Yam; Dickens, Michael P.; Garcia, Marcos D.; Jenkins, Paul R.; Mahale, Sachin; Chaudhuri, Bhabatosh Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 16 p. 6073 - 6084

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Citation Number: 22

Abstract

We present the design, synthesis and biological activity of a new series of substituted 3-(2- (1H-indol-1-yl) ethyl)-1H-indoles and 1, 2-di (1H-indol-1-yl) alkanes as selective inhibitors of CDK4/cyclin D1. The compounds were designed to explore the relationship between the connection mode of the indolyl moieties and their CDK inhibitory activities. We found all the above-mentioned designed compounds to be selective inhibitors of CDK4/cyclin D1 ...