Il Farmaco

Heterocyclic isosters of antimycobacterial salicylanilides

J Matyk, K Waisser, K Dražková, J Kuneš, V Klimešová…

Index: Matyk, Josef; Waisser, Karel; Drazkova, Katerina; Kunes, Jiri; Klimesova, Vera; Palat Jr., Karel; Kaustova, Jarmila Farmaco, 2005 , vol. 60, # 5 p. 399 - 408

Full Text: HTML

Citation Number: 22

Abstract

A series of 64 derivatives of substituted heterocyclic analogues of salicylanilides was synthesized. The compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii. For the QSAR study, the combination of Free–Wilson approach with Hansch approach was used. The molecules were separated on the heterocyclic and salicyl ...

Related Articles:

Synthesis and biological activity of analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid: discovery of a novel aminoguanidinoacetic acid …

[Hurd; Hayao Journal of the American Chemical Society, 1955 , vol. 77, p. 117,119]

Synthesis and biological activity of analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid: discovery of a novel aminoguanidinoacetic acid …

[Hurd; Hayao Journal of the American Chemical Society, 1955 , vol. 77, p. 117,119]

Stripping voltammetric methods for determination of the antiparasitic drug nitazoxanide in bulk form, pharmaceutical formulation and human serum

[El-Desoky, Hanaa S.; Ghoneim, Mohamed M.; Abdel-Galeil, Mohamed M. Journal of the Brazilian Chemical Society, 2010 , vol. 21, # 4 p. 669 - 679]

More Articles...