Synthesis and cardiotonic activity of 6, 7-dimethoxyquinazoline derivatives

VP Morgalyuk, VA Azimov, VA Bondarenko…

Index: Morgalyuk, V. P.; Azimov, V. A.; Bondarenko, V. A.; Denisov, A. V.; Yuzhakov, S. D.; et al. Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 1 p. 15 - 21 Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 1 p. 28 - 32

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Abstract

Congestive heart failure is very widespread. More than 50% of 3-4 million patients with congestive heart failure die in one year within the USA [3, 22]. ... Acute and chronic congestive heart failure, refractoriness to therapy with cardiac glycosides, diuretics, and vasodilators, remains one of the major causes of death in patients with heart diseases [15, 18, 26]. ... Since reduced myocardial contractility is an important pathophysiologic factor in cardiac failure and ...