Biocatalyzed Enantioselective Reduction of Activated C= C Bonds: Synthesis of Enantiomerically Enriched α??Halo?螃漫?arylpropionic Acids

…, A Manfredi, D Monti, F Parmeggiani

Index: Brenna, Elisabetta; Gatti, Francesco G.; Manfredi, Alessia; Monti, Daniela; Parmeggiani, Fabio European Journal of Organic Chemistry, 2011 , # 20-21 p. 4015 - 4022

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Citation Number: 12

Abstract

Abstract The enantioselective biocatalyzed reduction of the C= C bond of some (Z)-methyl α- halo-β-arylacrylates was investigated. The reaction was performed by baker's yeast fermentation and Old Yellow Enzymes 1–3 mediated biotransformations. The final products were, respectively, enantiomerically enriched (S)-α-halo-β-arylpropionic acids and their methyl esters, and ester hydrolysis was promoted in the whole cell system. High ...