Tetrahedron

Synthesis of bone-targeted oestrogenic compounds for the inhibition of bone resorption

…, I Mansfield, MJ McKenzie, WB Bowler, JA Gallagher

Index: Bulman Page, Philip C; Moore, Jonathan P.G; Mansfield, Ian; McKenzie, Michael J; Bowler, Wayne B; Gallagher, James A Tetrahedron, 2001 , vol. 57, # 9 p. 1837 - 1847

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Citation Number: 49

Abstract

Syntheses have been realised for several members of a new class of potential bone resorption inhibitors consisting of steroidal oestrogenic compounds linked at the 17 position to a geminal bis (phosphonic acid) moiety through an ester linkage. The approach used has the potential to allow other biologically active compounds to be coupled to the geminal bisphosphonate unit.