Indium??Catalyzed Synthesis of Keto Esters from Cyclic 1, 3??Diketones and Alcohols and Application to the Synthesis of Seratrodast

…, A Kawata, T Noborio, S Yamamoto…

Index: Kuninobu, Yoichiro; Kawata, Atsushi; Noborio, Taihei; Yamamoto, Syun-Ichi; Matsuki, Takashi; Takata, Kazumi; Takai, Kazuhiko Chemistry - An Asian Journal, 2010 , vol. 5, # 4 p. 941 - 945

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Citation Number: 5

Abstract

Abstract Esterification reactions from cyclic 1, 3-diketones and alcohols are carried out in the presence of several Lewis acids. In particular, indium (III) triflate, In (OTf) 3, iron (III) triflate, Fe (OTf) 3, copper (II) triflate, Cu (OTf) 2, and silver (I) triflate, AgOTf, show high catalytic activities. These reactions proceed through the carbon–carbon bond cleavage by a retro- aldol reaction and were found to be highly regioselective even in the presence of other ...