Practical Synthesis of N-{4-[(2-Methyl-4, 5-dihydroimidazo [4, 5-d][1] benzazepin-6 (1 H)-yl) carbonyl] phenyl} biphenyl-2-carboxamide Monohydrochloride: an …
T Tsunoda, A Yamazaki, H Iwamoto…
Index: Organic Process Research and Development, , vol. 7, # 6 p. 883 - 887
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Abstract
... Organic Process Research & Development. ... This straightforward process provides a 2-fold increase in the yield of YM087 over the discovery synthesis with respect to ... The key features of this procedure are (1) a reliable imidazole formation from α-bromoketones by controlling the ...
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[Tsunoda, Takashi; Yamazaki, Atsuki; Iwamoto, Hidenori; Sakamoto, Shuichi Organic Process Research and Development, 2003 , vol. 7, # 6 p. 883 - 887]
[Tsunoda, Takashi; Yamazaki, Atsuki; Iwamoto, Hidenori; Sakamoto, Shuichi Organic Process Research and Development, 2003 , vol. 7, # 6 p. 883 - 887]