Synthesis of 5-(trifluoromethyl) cyclohexane-1, 3-dione and 3-amino-5-(trifluoromethyl) cyclohex-2-en-1-one: new trifluoromethyl building block

OO Fadeyi, CO Okoro

Index: Fadeyi, Olugbeminiyi O.; Okoro, Cosmas O. Tetrahedron Letters, 2008 , vol. 49, # 32 p. 4725 - 4727

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Citation Number: 6

Abstract

A simple synthesis of 5-(trifluoromethyl) cyclohexane-1, 3-dione and 3-amino-5- (trifluoromethyl) cyclohex-2-en-1-one from the sodium salt of methyl or ethyl-4-hydroxy-2- oxo-6-(trifluoromethyl) cyclohex-3-en-1-oate is demonstrated. The compounds represent highly functionalized reactive intermediates for the synthesis of organic and heterocyclic compounds containing a trifluoromethyl group.