Structure-activity relationships of potent, selective inhibitors of neuronal nitric oxide synthase based on the 6-phenyl-2-aminopyridine structure

…, K Ward, S Faraci, K Verdries, P Seymour…

Index: Lowe III, John A.; Qian, Weimin; Drozda, Susan E.; Volkmann, Robert A.; Nason, Deane; Nelson, Robert B.; Nolan, Charles; Liston, Dane; Ward, Karen; Faraci, Steve; Verdries, Kim; Seymour, Pat; Majchrzak, Michael; Villalobos, Anabella; White, W. Frost Journal of Medicinal Chemistry, 2004 , vol. 47, # 6 p. 1575 - 1586

Full Text: HTML

Citation Number: 28

Abstract

The synthesis and structure-activity relationships of a series of 6-phenyl-2-aminopyridines that potently and selectively inhibit the neuronal isoform of nitric oxide synthase (nNOS) are described. Compound 14bi from this series exhibits potent in vivo activity in harmaline- ...