Towards the synthesis of bisubstrate inhibitors of protein farnesyltransferase: Synthesis and biological evaluation of new farnesylpyrophosphate analogues

…, L Coudray, E Mouray, P Grellier, J Dubois

Index: Duez, Stephanie; Coudray, Laetitia; Mouray, Elisabeth; Grellier, Philippe; Dubois, Joelle Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 2 p. 543 - 556

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Citation Number: 12

Abstract

Protein farnesyltransferase (FTase) has recently appeared as a new target of parasitic diseases, a field poor in drugs in development. With the aim of creating new bisubstrate inhibitors of FTase, new farnesyl pyrophosphate analogues have been studied. Farnesyl ...