Difluorinated malonaldehyde derivatives as useful difluoromethylene-containing building blocks

T Tsukamoto, T Kitazume

Index: Tsukamoto, Takashi; Kitazume, Tomoya Journal of the Chemical Society, Chemical Communications, 1992 , # 7 p. 540 - 541

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Citation Number: 9

Abstract

New CF2-containing building blocks, ethyl 3-ethoxy-2, 2-difluoro-3-hydroxy-propionate and- propioamide, were prepared via formylation of α, α-difluorinated Reformatsky reagents, and reacted with active methylene compounds, nitromethane or phosphonoacetate to afford α, α- difluoro-functionalized esters and amides.