Tetrahedron letters

Naphthalene-catalysed lithiation of 3-chloro-2-chloromethyl-propene: A barbier-type practical alternative to the trimethylenemethane dianion

DJ Ramón, M Yus

Index: Ramon, Diego J.; Yus, Miguel Tetrahedron Letters, 1992 , vol. 33, # 16 p. 2217 - 2220

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Citation Number: 50

Abstract

Abstract The reaction of equimolar amounts of 3-chloro-2-chloromethylpropene (2) and a carbonyl compound (3) with an excess of lithium powder and a catalytic amount (6%) of naphthalene in tetrahydrofuran at− 78 C leads, after hydrolysis with water, to the