Tetrahedron

Chiral derivatives of Butenafine and Terbinafine: synthesis and antifungal activity

…, E Otterholt, H Høgmoen, E Sundby, C Charnock…

Index: Fuglseth, Erik; Otterholt, Eli; Hogmoen, Hanne; Sundby, Eirik; Charnock, Colin; Hoff, Bard Helge Tetrahedron, 2009 , vol. 65, # 47 p. 9807 - 9813

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Citation Number: 13

Abstract

Two series of allylamines/benzylamines have been synthesised and evaluated for their antifungal activity towards Cryptococcus neoformans. All compounds are chiral derivatives of Butenafine and Terbinafine, having additional substituents at the carbon connected to the central nitrogen atom. In both series, the antifungal activity was strongly dependent on both the steric bulk and the electronic nature of the substituents. Compared to the parent ...

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