Synthesis and biological evaluation of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives with both COX and LOX inhibitory activity

M Akhter, N Akhter, MM Alam, MS Zaman…

Index: Akhter, Mymoona; Akhter, Nayeema; Alam; Zaman; Saha, Rikta; Kumar Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 6 p. 767 - 776

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Citation Number: 9

Abstract

Dual cyclooxygenase/lipoxygenase (COX/LOX) inhibitors constitute a valuable alternative to classical nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors for the treatment of inflammatory diseases. A series of 3-(5-phenyl/phenylamino-[1, 3, 4] oxadiazol-2-yl)-chromen-2-one and N-[5-(2-oxo-2 H-chromen-3-yl)-[1, 3, 4] oxadiazol-2-yl]- benzamide derivatives were synthesized and screened for anti-inflammatory, analgesic ...

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