Studies on the enantioselective oxidation of β-ionone with a whole E. coli system expressing cytochrome P450 monooxygenase BM3

D Zehentgruber, VB Urlacher, S Lütz

Index: Zehentgruber, Daniela; Urlacher, Vlada B.; Luetz, Stephan Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 84, p. 62 - 64

Full Text: HTML

Citation Number: 7

Abstract

Recombinant Escherichia coli cells, expressing an NADH-dependent cytochrome P450 monooxygenase BM-3 mutant, were used for the hydroxyalation of the sesquiterpenoid β- ionone to (R)-4-hydroxy-β-ionone. The decrease in enantioselectivity of cytochrome P450 monooxygenase BM-3 catalyzed hydroxylation of β-ionone can be ascribed to the overoxidation of the desired product. In this initial study we report, that by addressing ...

Related Articles:

A convenient cross-metathesis approach to trisporins

[Lopez-Sanchez, Cristobal; Hernandez-Cervantes, Carmen; Rosales, Antonio; Alvarez-Corral, Miriam; Munoz-Dorado, Manuel; Rodriguez-Garcia, Ignacio Tetrahedron, 2009 , vol. 65, # 46 p. 9542 - 9549]

… of P450 BM??3 and an NADP+ Cofactor Recycling System: Towards a Technical Application of Heme??Containing Monooxygenases in Fine Chemical Synthesis

[Maurer, Steffen C.; Schulze, Holger; Schmid, Rolf D.; Urlacher, Vlada Advanced Synthesis and Catalysis, 2003 , vol. 345, # 6-7 p. 802 - 810]

A synthetic approach to taxane diterpenes. A synthesis of the bicyclo [5.3. 1] undecenone ring system

[Ohtsuka, Yasuo; Oishi, Takeshi Tetrahedron Letters, 1986 , vol. 27, # 2 p. 203 - 206]

Structural analysis of CYP101C1 from Novosphingobium aromaticivorans DSM12444

[Ma, Ming; Bell, Stephen G.; Yang, Wen; Hao, Yiming; Rees, Nicholas H.; Bartlam, Mark; Zhou, Weihong; Wong, Luet-Lok; Rao, Zihe ChemBioChem, 2011 , vol. 12, # 1 p. 88 - 99]

Selective allylic electro-oxidation of α-and β-ionones

[Guirado, Antonio; Moss, Gerard P.; Utley, James H. P. Journal of the Chemical Society, Chemical Communications, 1987 , # 2 p. 41 - 42]

More Articles...