2-(2-Hydrazinyl) thiazole derivatives: Design, synthesis and in vitro antimycobacterial studies

P Makam, R Kankanala, A Prakash…

Index: Makam, Parameshwar; Kankanala, Ramakrishna; Prakash, Amresh; Kannan, Tharanikkarasu European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 564 - 576

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Citation Number: 30

Abstract

Abstract In an attempt to discover new potent inhibitors for Mycobacterium tuberculosis (Mtb), a series of 2-(2-hydrazinyl) thiazole derivatives with a wide range of substitutions at 2-, 4-and 5-positions were designed by considering Lipinski rule. The designed compounds were synthesized, characterized and evaluated for their inhibitory potential against Mtb, H 37 Rv, by in vitro assay. The compounds, ethyl-4-methyl-2-[(E)-2-[1-(pyridin-2-yl) ...