Synthesis of inhibitors of 2, 3-oxidosqualene-lanosterol cyclase. 2. Cyclocondensation of. gamma.,. delta.-unsaturated-. beta.-keto esters with imines

…, AC Oehlschlager, NH Georgopapadakou…

Index: Dodd; Oehlschlager; Georgopapadakou; Polak; Hartman Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7226 - 7234

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Citation Number: 50

Abstract

Synthesis and the biological evaluation of ammonium ion analogues of the fmt carbocyclic cationic intermediate 4 preaumed to formed during the cyclization of 2, 3-oxidosqualene to protosterol, 2, by 2, 3-oxidosqualenelanosterol cyclase (OSC) is presented. Preparation of ...

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