Factors influencing the antifolate activity of synthetic tea-derived catechins
M Sáez-Ayala, MP Fernández-Pérez, S Chazarra…
Index: Saez-Ayala, Magali; Fernandez-Perez, Maria Piedad; Chazarra, Soledad; McHedlishvili, Nani; Tarraga-Tomas, Alberto; Rodriguez-Lopez, Jose Neptuno Molecules, 2013 , vol. 18, # 7 p. 8319 - 8341
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Citation Number: 3
Abstract
Abstract: Novel tea catechin derivatives have been synthesized, and a structure-activity study, related to the capacity of these and other polyphenols to bind dihydrofolate reductase (DHFR), has been performed. The data showed an effective binding between all molecules and the free enzyme, and the dissociation constants of the synthetic compounds and of the natural analogues were on the same order. Polyphenols with a catechin configuration ...