Synlett

A Tandem Amination/Lactamisation Route to 2-Azabicyclo [2.2. 2] octanones

JD Cuthbertson, AA Godfrey, RJK Taylor

Index: Cuthbertson, James D.; Godfrey, Andrew A.; Taylor, Richard J. K. Synlett, 2010 , # 18 p. 2805 - 2807

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Citation Number: 2

Abstract

Abstract An efficient one-pot amination/lactamisation sequence for the preparation of 2- azabicyclo [2.2. 2] octanones from 6-carboalkoxycyclohex-2-enones and aqueous ammonia is described. Scope and limitation studies are reported for this tandem procedure and a range of bicyclic compounds have been prepared, two of which were characterised by X-ray crystallography.

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