Advanced Synthesis & Catalysis

The Iridium??Catalyzed Synthesis of Symmetrically and Unsymmetrically Alkylated Diamines under Mild Reaction Conditions

S Michlik, T Hille, R Kempe

Index: Michlik, Stefan; Hille, Toni; Kempe, Rhett Advanced Synthesis and Catalysis, 2012 , vol. 354, # 5 p. 847 - 862

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Citation Number: 55

Abstract

Abstract An iridium catalyst–stabilized by an anionic P, N ligand–was used for the symmetrical and unsymmetrical monoalkylation of para-, meta-, and ortho- benzenediamines. Benzyl and aliphatic alcohols were used as alkylating reagents. 28 derivatives were synthesized. 14 of them are new compounds. Furthermore, the alkylation of the pharmacological important diamine Dapson®(dapsone) is described. 14 dapsone ...