Pyrimidinone antibiotics—heterocyclic analogues with improved antibacterial spectrum

…, YC Grande, R Endermann, R Gahlmann…

Index: Brands, Michael; Grande, Yolanda Cancho; Endermann, Rainer; Gahlmann, Reinhold; Krueger, Jochen; Raddatz, Siegfried Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 16 p. 2641 - 2645

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Citation Number: 24

Abstract

We report the synthesis and pharmacological evaluation of new derivatives of the natural dipeptide antibiotic TAN 1057 A, B containing heterocycles either in the β-amino acid side chain or as mimics of the urea function. In the course of this program, we identified novel analogues that display activity towards a broader panel of Gram-positive bacteriae.