Synthetic communications

Ortholithiation of Unprotected Benzoic Acids: Application for Novel 2??Chloro??6??Substituted Benzoic Acid Syntheses

F Gohier, AS Castanet, J Mortier

Index: Gohier, Frederic; Castanet, Anne-Sophie; Mortier, Jacques Synthetic Communications, 2005 , vol. 35, # 6 p. 799 - 806

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Citation Number: 8

Abstract

2??Chloro??6??substituted benzoic acids of the type 2a–h were prepared by the tandem metallation sequence from 2??chlorobenzoic acid 1 with the 1:1 complex sec??butyllithium/TMEDA in THF at −78°C followed by quenching with electrophiles. ... 2??Chloro??6??substituted benzoic acids of the type 2a–h were prepared by the tandem metallation sequence from 2??chlorobenzoic acid 1 with the 1:1 complex sec??butyllithium/TMEDA in THF at −78°C followed by quenching ...