Synthesis of E-and Z-pyrazolylacrylonitriles and their evaluation as novel antioxidants

…, AK Prasad, SK Singh, N Kumar, S Mukherjee…

Index: Parmar, Virinder S.; Kumar, Ajay; Prasad, Ashok K.; Singh, Sanjay K.; Kumar, Naresh; Mukherjee, Shubhasish; Raj, Hanumantharao G.; Goel, Sanjay; Errington, William; Puar, Mohindar S. Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 7 p. 1425 - 1436

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Citation Number: 29

Abstract

A facile synthesis of (Z)-and (E)-2-(5-arylpyrazol-3-yl)-3-(pyrrol-2-yl) acrylonitriles and (Z)-2- (1, 3-diarylpyrazol-5-yl)-3-(pyrrol-2-yl) acrylonitriles, and isomerisation of (Z)-2-(5- arylpyrazolyl) acrylonitriles to (E)-2-(5-arylpyrazolyl) acrylonitriles under basic conditions have been reported.(Z)-2-(1, 3-Diarylpyrazolyl) acrylonitriles did not undergo isomerisation under the similar conditions. New compounds were identified on the basis of their spectral ...