Synthesis of Indolobenzazepinones by Application of an Isocyanide??Based Multicomponent Reaction

S Beaumont, P Retailleau, P Dauban…

Index: Beaumont, Stephane; Retailleau, Pascal; Dauban, Philippe; Dodd, Robert H. European Journal of Organic Chemistry, 2008 , # 30 p. 5162 - 5175

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Citation Number: 15

Abstract

Abstract Application of a Ugi multicomponent reaction to oxo acids 4 allows the formation of potentially antimitotic indolobenzazepinones of type 5 in good yields of up to 72%, whereas the same transformation from the starting substrate 6 gives access to analogues of paullone with yields of up to 89%. The reaction could be applied to a wide range of isocyanides, thereby ensuring introduction of molecular diversity at the key C-5 position. Use of ...