Synthesis of an 4??oxo??1, 4??dihydropyridinomethylidene substituted 2??indolinone

A Lumetzberger, W Loewe, M Weber…

Index: Lumetzberger, Astrid; Loewe, Werner; Weber, Manuela; Luger, Peter Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 1 p. 155 - 159

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Abstract

The 3-substituted 2-indolinones have been designed as a novel class of tyrosine kinase inhibitors, which exhibit selectivity toward different receptor tyrosine kinases (RTKs)[1]. Investigations led to SU 5416, which is a potent and selective inhibitor of the vascular endothelial growth factor receptor (VEGF, Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization and growth of multiple tumor types [2]. In order to get a similar ...