Tetrahedron letters

Synthesis of gem-difluoromethylenated biflavonoid via the Suzuki coupling reaction

X Zheng, WD Meng, FL Qing

Index: Zheng, Xing; Meng, Wei-Dong; Qing, Feng-Ling Tetrahedron Letters, 2004 , vol. 45, # 43 p. 8083 - 8085

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Citation Number: 34

Abstract

gem-Difluoromethylenated biflavonoid was synthesized via the Suzuki coupling reaction. The key intermediate 6-iodonated flavone was regioselectively synthesized by the use of AgOAc/I2 under mild conditions without handling of a strongly toxic reagent. The key step was the formation of a flavone 3′-boronate using a palladium-catalyzed exchange of the corresponding 3′-iodonated flavone with a diboron reagent.