Topologically constrained bifunctional intercalators: DNA intercalation by a macrocyclic bisacridine

SC Zimmerman, CR Lamberson, M Cory…

Index: Zimmerman, Steven C.; Lamberson, Carol R.; Cory, Michael; Fairley, Terri A. Journal of the American Chemical Society, 1989 , vol. 111, # 17 p. 6805 - 6809

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Citation Number: 47

Abstract

Abstract: A topologically novel DNA bifunctional intercalator, 4, has been synthesized and its DNA binding compared with the binding of the monointercalator 9-aminoacridine (6) and spermine bisacridine (5), a known bisintercalator. Water-soluble macrocyclic bisacridine 4 was synthesized by reaction of 4-(bromomethyl)-9-~ hloroacridine with N, N'-bis (2- mercaptoethy1) succinamide and base. The resulting dichloride was converted to the ...