2, 5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors

…, H Xia, K Fandrick, R Johnson, A Janowsky…

Index: Voelker, Troy; Xia, Haiji; Fandrick, Keith; Johnson, Robert; Janowsky, Aaron; Cashman, John R. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 5 p. 2047 - 2068

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Citation Number: 6

Abstract

Enhancement of 5-hydroxytryptamine (5-HT, serotonin) neurotransmission is a viable means of treating depression. On the basis of this observation, agents that inhibit re-uptake of 5-HT were prepared based on (−)-cocaine and aryltropanes as lead compounds because they are reasonably potent 5-HT re-uptake inhibitors. Molecular dissection of an aryltropane provided a series of 5-and 6-membered ring compounds. From among this library of ...