Discovery of simplified N 2-substituted pyrazolo [3, 4-d] pyrimidine derivatives as novel adenosine receptor antagonists: Efficient synthetic approaches, biological …

…, SL Cheong, K Vamsikrishna, S Federico…

Index: Venkatesan, Gopalakrishnan; Paira, Priyankar; Cheong, Siew Lee; Vamsikrishna, Kosaraju; Federico, Stephanie; Klotz, Karl-Norbert; Spalluto, Giampiero; Pastorin, Giorgia Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 5 p. 1751 - 1765

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Citation Number: 4

Abstract

Abstract In the present study, a molecular simplification approach was employed to design novel bicyclic pyrazolo [3, 4-d] pyrimidine (PP) derivatives from tricyclic pyrazolo [4, 3-e]-1, 2, 4-triazolo-[1, 5-c] pyrimidines (PTP) as promising human A 3 adenosine receptor (hA 3 AR) antagonists. All the target compounds were synthesized using novel and efficient synthetic schemes and the structure–activity relationship studies of these PPs were explored ...