Formation of nitrosamines by alkylation of diazotates

…, AL Peyton, RJ Weinkam

Index: Cooper, Curt S.; Peyton, Albert L.; Weinkam, Robert J. Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 4116 - 4119

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Citation Number: 7

Abstract

In the study of the metabolic activation of procarbazine, a chemotherapeutic agent used in the treatment of Hodgkins disease (tumors of the brain and other neoplasms), two azoxy isomers were identified as metabolite~.'-~ Further metabolism of these azoxy compounds should lead to an alkylating species.*~~ A regiospecific synthesis of each of these unsymmetrical compounds or their unsubstituted analogues was desired to provide an ...

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