A general method for the preparation of chiral TREN derivatives

…, E Brulé, L Hagberg, F Lake, C Moberg

Index: Pei, Yuxin; Brade, Katja; Brule, Emilie; Hagberg, Lars; Lake, Fredrik; Moberg, Christina European Journal of Organic Chemistry, 2005 , # 13 p. 2835 - 2840

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Citation Number: 7

Abstract

Abstract A general procedure for the preparation of C 3-symmetric TREN derivatives with backbone chirality has been developed. Stereo-and regioselective ring opening by ammonia of (S)-N-tosyl-2-isopropylaziridine, obtained starting from either the corresponding amino alcohol or amino acid, followed by deprotection of the amino groups afforded the parent chiral TREN compound in high overall yield. In addition to TREN compounds with ...

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