Cyclopropamitosenes, novel bioreductive anticancer agents. Synthesis, electrochemistry, and biological activity of 7-substituted cyclopropamitosenes and related …

…, RJ Mortimer, CL Norton, N O'Sullivan…

Index: Cotterill, Ann S.; Moody, Christopher J.; Mortimer, Roger J.; Norton, Claire L.; O'Sullivan, Noeleen; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 22 p. 3834 - 3843

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Citation Number: 61

Abstract

The synthesis of the indolequinones 8 and 9 starting from methyl 4-(benzyloxy)-5-methoxy- indole-2-carboxylate (10) is described. The methoxy group in the indolequinones 1, 2, 4, 5, and 7-9 can be displaced by various nitrogen nucleophiles (ammonia, 2- methoxyethylamine, aziridine, 2-methylaziridine, pyrrolidine) in 22-88% yield. The resulting amino-substituted quinones, together with their methoxy precursors, were studied by ...

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