European Journal of Organic Chemistry 2017-10-09

One-Pot Synthesis of 2-(Aryl/Alkyl)amino-3-cyanobenzo[b]thiophenes and Their Hetero-Fused Analogues by Pd-Catalyzed Intramolecular Oxidative C–H Functionalization/Arylthiolation

Bonagiri Saraiah, Vibha Gautam, Anand Acharya, Mohamed A. Pasha, Ila Hiriyakkanavar

Index: 10.1002/ejoc.201700963

Full Text: HTML

Abstract

An efficient one-pot synthesis has been developed for substituted 2-(aryl/alkyl)amino-3-cyanobenzo[b]thiophenes and their hetero-fused analogues by using (hetero)arylacetonitriles and aryl/alkyl isothiocyanates in a PdII-catalyzed C–H functionalization/arylthiolation reaction. Some of the 2-arylamino-3-cyanobenzo[b]thiophenes were successfully converted into benzothieno[2,3-b]quinolones. DMSO = dimethyl sulfoxide; Tf = trifluoromethanesulfonyl; DCE = 1,2-dichloroethane.

Latest Articles:

Development of Photoactivatable Nitroxyl (HNO) Donors Incorporating the (3‐Hydroxy‐2‐naphthalenyl)methyl Phototrigger

2018-04-15

[10.1002/ejoc.201800092]

Catalytic C‐Alkylation of Pyrroles with Primary Alcohols: Hans Fischer's Alkali and a New Method with Iridium P,N,P‐Pincer Complexes

2018-03-30

[10.1002/ejoc.201800146]

Fluorine‐Containing Functionalized Cyclopentene Scaffolds Through Ring Contraction and Deoxofluorination of Various Substituted Cyclohexenes

2018-03-30

[10.1002/ejoc.201800057]

Verdazyl Radical Building Blocks: Synthesis, Structure, and Sonogashira Cross‐Coupling Reactions

2018-03-30

[10.1002/ejoc.201701783]

Iron‐Catalyzed Sulfur‐Promoted Decyanative Redox Condensation of o‐Nitrophenols and Arylacetonitriles: An Unprecedented Route to 2‐Arylbenzoxazoles

2018-03-30

[10.1002/ejoc.201701607]

More Articles...