Synthesis and antiplatelet, antiinflammatory and antiallergic activities of 2, 3-disubstituted 1, 4-naphthoquinones.

JC Lien, LJ Huang, JP Wang, CM Teng…

Index: Lien, Jin-Cherng; Huang, Li-Jiau; Wang, Jih-Pyang; Teng, Che-Ming; Lee, Kuo-Hsiung; Kuo, Sheng-Chu Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 6 p. 1181 - 1187

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Citation Number: 39

Abstract

Modification of 2-acetamido-3-chloro-1, 4-naphthoquinone, which has potent antiplatelet, antiallergic and antiinflammatory activities, led to a series of 2, 3-disubstituted 1, 4- naphthoquinones. Some of these compounds showed significant antiplatelet, antiallergic and antiinflammatory activities. Among them, 2-methoxy-3-chloro-1, 4-naphthoquinone (15) and 2-ethoxy-3-chloro-1, 4-naphthouinone (17) exhibited potent inhibitory effects on ...