Imidazole tethered oligodeoxyribonucleotides: synthesis and RNA cleaving activity

…, E Azhayeva, A Azhayev, H Lonnberg

Index: Hovinen; Guzaev; Azhayeva; Azhayev; Lonnberg Journal of Organic Chemistry, 1995 , vol. 60, # 7 p. 2205 - 2209

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Citation Number: 87

Abstract

A solid support (3) and a non-nucleosidic phosphoramidite building block (41, both containing a thioester bond in their structure, were synthesized. They were used in the preparation of oligonucleotides tethered to an imidazole group at their 3'-or 5'-terminus, as well as at the 1 '-position of nonterminal 3'-deoxypsicothymidine units. The desired functional groups were introduced during the deprotection of the oligonucleotide by using ...