Tetrahedron

Regioselective palladium-catalyzed cross-coupling reactions in the synthesis of novel 2, 3-disubstituted thiophene derivatives

R Pereira, B Iglesias, AR de Lera

Index: Pereira, Raquel; Iglesias, Beatriz; De Lera, Angel R Tetrahedron, 2001 , vol. 57, # 37 p. 7871 - 7881

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Citation Number: 57

Abstract

A reactivity optimization study of the palladium-catalyzed cross-coupling reactions of 2, 3- dibromothiophene and organometallic reagents has been conducted. Regioselective coupling at the C2 position, accomplished most notably by Suzuki coupling, was combined with a Stille reaction at C3 using Fu's modification, to afford the 2, 3-disubstituted thiophene derivatives.

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