Tetrahedron Letters
N6 (N-methyl-2-pyrrolidine amidine) deoxyadenosine-a new deoxynucleoside protecting group
LJ McBride, MH Caruthers
Index: McBride, L. J.; Caruthers, M. N. Tetrahedron Letters, 1983 , vol. 24, # 29 p. 2953 - 2956
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Citation Number: 52
Abstract
Abstract The synthesis and characterization of N 6 (N-methyl-2-pyrrolidine amidine) 2′- deoxyadenosine is described. This amidine is significantly more stable toward acid catalyzed depurination than N-benzoyldeoxyadenosine, is easy to prepare and can be removed rapidly and quantitatively.
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