Molecular Recognition of. beta.-Ribofuranosides by Synthetic Polypyridine-Macrocyclic Receptors

…, T Miyake, M Furusyo, H Nakazumi

Index: Inouye, Masahiko; Miyake, Toshiyuki; Furusyo, Masaru; Nakazumi, Hiroyuki Journal of the American Chemical Society, 1995 , vol. 117, # 50 p. 12416 - 12425

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Citation Number: 102

Abstract

Abstract: Artificial ribofuranoside receptors were designed and synthesized. The design of the polypyridinemacrocyclic receptors was based on the multipoint hydrogen bond complementarity between the receptors and methyl/3-D-ribofuranoside. The binding affinity of the receptors for the ribofuranoside in CDCl3 was very high (up to Ka= 5.2 x lo3 M-'), so that even native ribose was extracted by them into such nonpolar solvents. Selective ...