Enantioselective Michael additions to α, β-unsaturated imides catalyzed by a salen-Al complex

MS Taylor, EN Jacobsen

Index: Taylor, Mark S.; Jacobsen, Eric N. Journal of the American Chemical Society, 2003 , vol. 125, # 37 p. 11204 - 11205

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Citation Number: 235

Abstract

(Salen) aluminum complex 1b is an efficient catalyst for the conjugate addition of di-and trisubstituted nitriles to a wide range of acyclic alkyl-and aryl-substituted α, β-unsaturated imides. This new methodology provides access to multifunctional compounds that previously have not been readily accessible in enantioenriched form. Synthetic applications of these products include the preparation of enantiomerically enriched piperidines, as exemplified ...