Synthesis and biological evaluation of pyrroloiminoquinone derivatives
…, F Belinghieri, M Scarpellini, G Pratesi, F Zunino…
Index: Passarella, Daniele; Belinghieri, Francesca; Scarpellini, Michele; Pratesi, Graziella; Zunino, Franco; Gia, Ornella Maria; Via, Lisa Dalla; Santoro, Giuseppe; Danieli, Bruno Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 5 p. 2431 - 2438
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Citation Number: 16
Abstract
Synthesis of 10 pyrroloiminoquinone derivatives is presented. The strategy is based around the elaboration of a common intermediate by reaction with primary amines. All the compounds obtained have been subjected to antiproliferative activity with three different cell lines (NCI-H460, HeLa, and HL-60). The capacity of 4 selected compounds to affect the enzymatic activity of the nuclear enzyme DNA topoisomerase II and to form the typical ...
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