One-pot reductive N-alkylation with carbonyl compounds to give tertiary amines via borane reduction of imines

M Tokizane, K Sato, Y Sakami, Y Imori, C Matsuo…

Index: Tokizane, Masashi; Sato, Kaori; Sakami, Yuki; Imori, Yoichiro; Matsuo, Chika; Ohta, Tetsuo; Ito, Yoshihiko Synthesis, 2010 , # 1 p. 36 - 42

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Citation Number: 16

Abstract

Abstract One-pot synthesis of tertiary amines via borane-mediated reduction of imines and reductive N-alkylation with carbonyl compounds is described. This protocol's reducing agent is only borane in the reduction of imines, and additional reductant is not necessary in reductive N-alkylation step. When using more than two equivalents of aldehydes, reductive N-alkylation proceeded in good yield.

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