Hydroacylation of 4??[18F] fluorobenzaldehyde: a novel method for the preparation of 4′??[18F] phenylketones

NUH Khan, BC Lee, SY Lee, YS Choe…

Index: Khan, Noor-Ul Hasan; Lee, Byung Chul; Lee, Sang-Yoon; Choe, Yearn Seong; Jun, Chul-Ho; Chi, Dae Yoon Journal of Labelled Compounds and Radiopharmaceuticals, 2002 , vol. 45, # 12 p. 1045 - 1053

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Citation Number: 3

Abstract

Abstract To assess the potential of intermolecular hydroacylation reactions as a new fluorine- 18 labeling method, model reactions of [18 F] fluorobenzaldehyde with three different olefins (1-hexene (2a), allylbenzene (2b), and 3-phenoxypropene (2c)) in the presence of Wilkinson's catalyst were performed. The procedure gave high radiochemical yields (38– 62%) of [18 F] fluorophenylketones with short reaction times (15 min). The intermolecular ...