Tetrahedron: Asymmetry

Enzymatic preparation of optically active silylmethanol derivatives having a stereogenic silicon atom by hydrolase-catalyzed enantioselective esterification

T Fukui, T Kawamoto, A Tanaka

Index: Fukui, Toshiaki; Kawamoto, Takuo; Tanaka, Atsuo Tetrahedron: Asymmetry, 1994 , vol. 5, # 1 p. 73 - 82

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Citation Number: 30

Abstract

Abstract Kinetic resolution of ethylmethylphenylsilylmethanol, a primary alcohol having a stereogenic silicon atom, was tried by hydrolase-catalyzed enantioselective reactions. Among twenty kinds of hydrolases examined, a commercial crude papain preparation was found to exhibit the highest enantioselectivity with moderate activity toward the silicon- containing alcohol on esterification with 5-phenylpentanoic acid in an organic solvent ...