p??Toluenesulfonic Acid Promoted Annulation of 2??Alkynylanilines with Activated Ketones: Efficient Synthesis of 4??Alkyl??2, 3??Disubstituted Quinolines

…, Y Wang, L Liu, H Wang, J Zhao…

Index: Peng, Changlan; Wang, Yong; Liu, Lanying; Wang, Honggen; Zhao, Jiaji; Zhu, Qiang European Journal of Organic Chemistry, 2010 , # 5 p. 818 - 822

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Citation Number: 20

Abstract

Abstract Reactions between readily available 2-alkynylanilines and activated ketones such as β-keto esters promoted by p-toluenesulfonic acid afford 4-alkyl-2, 3-disubstituted quinolines in good to excellent yields. The generality of substituents at the other end of the triple bond of 2-alkynylanilines makes the method a valuable approach to diversified 4- alkylquinolines, which are difficult to obtain by classical methods such as the Friedländer ...