Ionic liquid/potassium hydroxide catalyzed solvent-free, one-pot synthesis of diarylglycolic acids from aromatic aldehydes under microwave

N Singh, SK Singh, RS Khanna, KN Singh

Index: Singh, Neetu; Singh, Satish Kumar; Khanna; Singh, Krishna Nand Tetrahedron Letters, 2011 , vol. 52, # 18 p. 2419 - 2422

Full Text: HTML

Citation Number: 12

Abstract

Preparation of benzilic acid from benzaldehyde is accomplished by a three-step approach involving conversion of benzaldehyde to benzoin, oxidation of benzoin to benzil, and finally benzilic acid rearrangement of benzil to afford the desired product. A multi-step synthesis of benzilic acid/ester from p-bromotoluene has also been investigated and described. 13 Formation of benzoin from benzaldehyde is usually achieved by using cyanide ion, 14 or ionic liquids. 15 The ...