Tetrahedron letters

Synthesis of pyrrolo [2, 1-c][1, 4] benzodiazepine antibiotics via azido reductive cyclization with HMDST

A Kamal, BSP Reddy, BSN Reddy

Index: Kamal, Ahmed; Reddy, B.S. Praveen; Reddy, B.S. Narayan Tetrahedron Letters, 1996 , vol. 37, # 37 p. 6803 - 6806

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Citation Number: 40

Abstract

A new facile synthesis of pyrrolo [2, 1-c][1, 4] benzodiazepine (PBD) ring system has been achieved by reductive cyclization of the azide employing hexamethyldisilathiane (HMDST). The parent unsubstituted PBD and the natural product DC-81 have also been prepared in good overall yields.

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