Environmentally benign syntheses of flavanones

PY Chen, TP Wang, MY Chiang, KS Huang, CC Tzeng…

Index: Chen, Po-Yuan; Wang, Tzu-Pin; Chiang, Michael Y.; Huang, Keng-Shian; Tzeng, Cherng-Chyi; Chen, Yi-Long; Wang, Eng-Chi Tetrahedron, 2011 , vol. 67, # 23 p. 4155 - 4160

Full Text: HTML

Citation Number: 12

Abstract

Abstract Mild and environmentally benign methods for the syntheses of flavanones are described. The reaction of o-hydroxyacetophenones (1) and benzaldehydes (2) in water in the presence of DABCO at room temperature gave 3-hydroxy-1-(2-hydroxylphenyl)-3- arylpropan-1-ones (3a–i) as intermediates. Followed by an intramolecular dehydration of the 3a–i with the modified Mitsunobu's reaction, the target flavanones (4a–i) were obtained. ...