Synlett

Versatile Synthesis of Bicyclo [9.3. 1] pentadecatriene for New Bicyclic Taxoids

S Shibuya, M Isobe

Index: Shibuya, Satoshi; Isobe, Minoru Synlett, 1998 , # 4 p. 373 - 374

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Citation Number: 4

Abstract

Abstract: A common carbon skeleton bicyclo [9.3. 1] pentadecatriene of taxachitrienes was synthesized in its des-methyl form in short steps. The key step was Nicholas-Hosomi type reaction in the acidic cyclization between ene-yne biscobalthexacarbonyl complex electrophile with allyltrimethylsilane nucleophile. Decomplexation of the biscobalthexacarbonyl was achieved with a tin hydride and NBS in 1, 4-cyclohexadiene ...

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